Effect of camel milk and pistachio-based product on cancer-induced sarcopenia in Sprague Dawley rats
DOI:
https://doi.org/10.5327/fst.13023Palavras-chave:
Cancer, sarcopenia, muscle mass, camel milk, pistachioResumo
In the current study, we investigated the role of camel milk and pistachio in the muscle growth of rats with cancer-induced sarcopenia. Female Sprague Dawley rats weighing 180 – 200 grams were selected for a bioefficacy trial for 13 weeks and divided into four groups: G1 (negative control), G2 (positive control), G3 (normal diet + camel milk), and G4 (normal diet + camel milk and pistachio based product). Tumors were induced in rats by administering 50 mg/kg of 7,12-dimethylbenz(a)anthracene via gastrogavage followed by chemotherapy in G2, G3, and G4. Histopathological analysis, muscle strength analysis, muscle fiber histology and renal function tests were performed. The administration of camel milk and pistachio-based product (CMP) significantly (P<0.01) improved muscle strength in the treatment group. Muscle mass analysis of the extensor digitorum longus (EDL) and soleus muscle showed significant (P<0.01) improvement in the treatment group. Muscle fiber diameter also significantly (P<0.01) increased in the treatment group. Camel milk and pistachio-based product (CMP) have shown promising effects against cancer-induced sarcopenia in rat modelling by enhancing muscle function and strength.
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Referências
AACC. (2011). Approved Methods of the American Association of Cereal Chemists
AACC, St. Paul, MN, USA.
AOAC. (2006). Official Methods of Analysis of Association of Official Analytical Chemists International. AOAC Press, Arlington, VA, USA.
Ahmad, T., Butt, M.Z., Aadil, R.M., Inam-ur-Raheem, M., Abdullah, Bekhit, A.E.D., Balthazar, C.F., Rocha, R.S., Esmerino, E.A., Freitas, M.Q., Silva, M.C., Sameen, A., Cruz, A.G. (2019). Impact of nonthermal processing on different milk enzymes. International Journal of Dairy Technology, 72(4), 481-495.
Akhouri, V., Kumari, M. & Kumar, A., (2020). Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats. Scientific Reports, 10(1), 1-10.
Alhaj, O.A. (2020). Exploring potential therapeutic properties of camel milk. In Handbook of research on health and environmental benefits of camel products. (pp. 123-154) IGI Global.
Anjanappa, M., Corden, M., Green, A., Roberts, D., Hoskin, P., McWilliam, A., & Choudhury, A. (2020). Sarcopenia in cancer: risking more than muscle loss. Technical innovations & patient support in radiation oncology, 16(1), 50-57.
Azam, F., Qaisrani, S. N., Khalique, A., Bibi, F., Akram, C. A., Naveed, S., & Pasha, T. N. (2019). Exploring nutritive profile, metabolizable energy, protein, and digestible amino acids contents of indigenous protein sources of different locations for male broilers. Poultry Science, 98(10), 4664-4672.
Barros, A. C. S., Muranaka, E. N. K., Mori, L. J., Pelizon, C. H. T., Iriya, K., Giocondo, G., & Pinotti, J. A. (2004). Induction of experimental mammary carcinogenesis in rats with 7, 12-dimethylbenz (a) anthracene. Revista do Hospital das Clínicas, 59(5), 257-261.
Benevenga, N.J., Calvert, C., Eckhert, C.D., Fahey, G.C. & Greger, J.L. (1995). Nutrient requirements of laboratory animals (1. ed.). Washington DC, National Academic Press.
Bentahila, R., Giraud, P., Decazes, P., Kreps, S., Nay, P., Chatain, A., Fabiano, E., & Durdux, C. (2022). The impact of sarcopenia on survival and treatment tolerance in patients with head and neck cancer treated with chemoradiotherapy. Cancer Medicine, 1(1), 1-10.
Blomstrand, E., Eliasson, J., Karlsson, H. K., & Köhnke, R. (2006). Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. The Journal of nutrition, 136(1), 269-273.
Bonetto, A., Andersson, D. C., & Waning, D. L. (2015). Assessment of muscle mass and strength in mice. BoneKEy reports, 4,(1), 732-742, 2015.
Bulló, M., Juanola-Falgarona, M., Hernández-Alonso, P., & Salas-Salvadó, J. (2015). Nutrition attributes and health effects of pistachio nuts. British Journal of Nutrition, 113(2), 79-93.
Cahill, L.C., Giacomelli, M.G., Yoshitake, T., Vardeh, H., Faulkner-Jones, B.E., Connolly J.L., Sun, C., & Fujimoto J.G. (2018). Rapid virtual hematoxylin and eosin histology of breast tissue specimens using a compact fluorescence nonlinear microscope. Laboratory investigation, 98(1), 150-160.
Cao, A., Ferrucci, L. M., Caan, B. J., & Irwin, M. L. (2022). Effect of exercise on sarcopenia among cancer survivors: a systematic review. Cancers, 14(3), 786-796.
Cooper, C., Fielding, R., Visser, M. V., Van Loon, L. J., Rolland, Y., Orwoll, E., Reid, K., Boonen, S., Dere, W., Epstein, S., Mitlak, B., Tsouderos, Y., Sayer, A.A., Rizzoli, R., Reginster, J.Y., & Kanis, J. A. (2013). Tools in the assessment of sarcopenia. Calcified tissue international, 93(1), 201-210.
El Baz, F. K., Salama, Z. A., Abdel Baky, H. H., & Gaafar, A. A. (2014). Hepatoprotective effect of sweet Fennel (Foenculum vulgare L.) methanol extract against carbon tetrachloride induced liver injury in rats. International Journal of Pharmaceutical Sciences Review and Research, 25(2), 194-201.
Emerich, D. F., Thanos, C. G., & Sanberg, P. R. (2008). Intraventricular implant of encapsulated CNTF-secreting fibroblasts ameliorates motor deficits in aged rats. Current aging science, 1(2), 105-111.
Fan, C., Georgiou, K. R., Morris, H. A., McKinnon, R. A., Keefe, D. M., Howe, P. R., & Xian, C. J. (2017). Combination breast cancer chemotherapy with doxorubicin and cyclophosphamide damages bone and bone marrow in a female rat model. Breast cancer research and treatment, 165(1), 41-51.
Feng, M., Feng, C., Yu, Z., Fu, Q., Ma, Z., Wang, F., Wang, F., & Yu, L. (2015). Histopathological alterations during breast carcinogenesis in a rat model induced by 7, 12-Dimethylbenz (a) anthracene and estrogen-progestogen combinations. International journal of clinical and experimental medicine, 8(1), 346-357.
Ferguson, L., & Haviland. D. 2016. Pistachio Production Manual. (1 ed.). UCANR Publications. Davis, California, USA.
Gomez-Cabrera, M. C., Garcia-Valles, R., Rodriguez-Mañas, L., Garcia-Garcia, F. J., Olaso-Gonzalez, G., Salvador-Pascual, A., Tarazona-Santabalbina, F.J., & Viña, J. (2017). A new frailty score for experimental animals based on the clinical phenotype: inactivity as a model of frailty. The Journals of Gerontology: Series A, 72(7), 885-891.
Granic, A., Hurst, C., Dismore, L., Davies, K., Stevenson, E., Sayer, A. A., & Aspray, T. (2019). Milk and resistance exercise intervention to improve muscle function in community-dwelling older adults at risk of sarcopenia (MIlkMAN): protocol for a pilot study. BMJ Open, 9(10), 1-10.
Hassan, S.A., Abbas, M., Zia, S., Maan, A.A., Khan, M.K.I., Hassoun, A., Shehzad, A., Gattin, R., Aadil, R.M. (2022). An appealing review on industrial and nutraceutical applications of pistachio waste. Critical Reviews in Food Science and Nutrition,
Hunt, C., Burn, P., & Adamczuk, Z. C. (1987). Proximal composition and fat type of three popular take‐away meals. International Journal of Food Science & Technology, 22(6), 669-675.
Ismaili, M. A., Saidi, B., Zahar, M., Hamama, A., & Ezzaier, R. (2019). Composition and microbial quality of raw camel milk produced in Morocco. Journal of the Saudi Society of Agricultural Sciences, 18(1), 17-21.
Jones K:Oral Dosing (Gavage) in Adult Mice and Rats SOP. (2015). UBC Animal Care Guideline, 1(1),1-7.
Kaskous, S., & Pfaffl, M. W. (2017). Bioactive properties of minor camel milk ingredients-An overview. Journal of Camel Practice and Research, 24(1), 15-26.
Kemmochi, Y., Ohta, T., Motohashi, Y., Kaneshige, A., Katsumi, S., Kakimoto, K., Yasui, Y., Anagawa-Nakamura, A., Toyoda, K., Taniai-Riya, E., Takahshahi, A., Shoda, T., & Yamada, T. (2018). Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats. Journal of toxicologic pathology, 31(2), 113-123.
Ko, C. H., Wu, S. J., Wang, S. T., Chang, Y. F., Chang, C. S., Kuan, T. S., Chuang, H., Chang, C., Chou, W., & Wu, C. H. (2020). Effects of enriched branched-chain amino acid supplementation on sarcopenia. Aging (Albany NY), 12(14), 15091-15103.
Kola, O., Hayoğlu, İ., Türkoğlu, H., Parıldı, E., Ak, B. E., & Akkaya, M. R. (2018). Physical and chemical properties of some pistachio varieties (Pistacia vera L.) and oils grown under irrigated and non-irrigated conditions in Turkey. Quality Assurance and Safety of Crops & Foods, 10(4), 383-388.
Lee, Y. J., Lee, M., Wi, Y. M., Cho, S., & Kim, S. R. (2020). Potassium intake, skeletal muscle mass, and effect modification by sex: data from the 2008–2011 KNHANES. Nutrition journal, 19(1), 1-9.
Lueders, B., Kanney, B. C., Krone, M. J., Gannon, N. P., & Vaughan, R. A. (2022). Effect of branched-chain amino acids on food intake and indicators of hunger and satiety-a narrative summary. Human Nutrition & Metabolism, 30(1),1-10.
Li, C. W., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., Miao, H., Cao, W., Liu, R., Jiang, L., Yu, S., Li, C., Liu, H., Xu, L., Liu, R., Zhang, X., & Liu, G. S. (2022). Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review. Journal of Cachexia, Sarcopenia and Muscle, 13(2), 781-794.
Mateos, R., Salvador, M. D., Fregapane, G., & Goya, L. (2022). Why Should Pistachio Be a Regular Food in Our Diet?. Nutrients, 14(15), 3207-3218.
Mohamad, A., Shah, N.N.A.K., Sulaiman, A., Adzahan, N.M., Aadil, R.M. (2020). Impact of the pulsed electric field on physicochemical properties, fatty acid profiling, and metal migration of goat milk. Journal of Food Processing and Preservation, 44(12), e14940.
Mohamad, A., Shah, N.N.A.K., Sulaiman, A., Adzahan, N.M., Aadil, R.M. (2021). Pulsed electric field (PEF) of goat milk: Impact on Escherichia coli ATCC 8739 and vitamin constituents. Journal of Food Process Engineering, 44(9), e-13779.
Montgomery DC. (2017). Design and Analysis of Experiments. John wiley & sons. Hoboken, New Jersey, USA.
Nemoto, A., & Goyagi, T. (2021). Tail suspension is useful as a sarcopenia model in rats. Laboratory Animal Research, 37(1), 1-7.
Patel, A., Rajesh, S., Chandrashekhar, V. M., Rathnam, S., Shah, K., Rao, C. M., & Nandakumar, K. (2013). A rat model against chemotherapy plus radiation-induced oral mucositis. Saudi Pharmaceutical Journal, 21(4), 399-403.
Petermann‐Rocha, F., Balntzi, V., Gray, S. R., Lara, J., Ho, F. K., Pell, J. P., & Celis‐Morales, C. (2022). Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta‐analysis. Journal of cachexia, sarcopenia and muscle, 13(1), 86-99.
Pötsch, M. S., Ishida, J., Palus, S., Tschirner, A., von Haehling, S., Doehner, W., Anker, S.D., & Springer, J. (2020). MT‐102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle, 11(2), 594-605.
Rocha, K. B. F., Oliveira, C. N., Azevedo, Í. M., Macedo, R. D., & Medeiros, A. C. (2019). Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model. Acta Cirúrgica Brasileira, 34(1),1-10.
Seleet, F. L., Assem, F. M., Abd El‐Gawad, M. A., Dabiza, N. M., & Abd El‐Salam, M. H. (2016). Development of a novel milk‐based fermented product fortified with wheat germ. International Journal of Dairy Technology, 69(2), 217-224.
Shakeel, K., Rabail, R., Iahtisham-Ul-Haq, Sehar, S., Nawaz, A., Manzoor, M.F., Walayat, N., Socol, C.T., Maerescu, C.M., Aadil, R.M. (2022). Camel milk protectiveness towards multiple liver disorders: A review. Frontiers in Nutrition, 9, 944842.
Stewart, L. K., Smoak, P., Hydock, D. S., Hayward, R., O'brien, K., Lisano, J. K., Boeneke, C., Christensen, M., & Mathias, A. (2019). Milk and kefir maintain aspects of health during doxorubicin treatment in rats. Journal of dairy science, 102(3), 1910-1917.
Thammitiyagodage, M. G., De Silva, N. R., Rathnayake, C., Karunakaran, R., Wgss, K., Gunatillka, M. M., Ekanayaka, N., Galhena, B.P., & Thabrew, M. I. (2020). Biochemical and histopathological changes in Wistar rats after consumption of boiled and un-boiled water from high and low disease prevalent areas for chronic kidney disease of unknown etiology (CKDu) in north Central Province (NCP) and its comparison with low disease prevalent Colombo, Sri Lanka. BMC nephrology, 21(1), 1-12.
Toledo, M., Busquets, S., Sirisi, S., Serpe, R., Orpi, M., Coutinho, J., Martinez, R., López-Soriano, F.J., & Argiles, J. M. (2011). Cancer cachexia: physical activity and muscle force in tumour-bearing rats. Oncology reports, 25(1), 189-193.
Tosato, M., Marzetti, E., Cesari, M., Savera, G., Miller, R. R., Bernabei, R., Landi, F., & Calvani, R. (2017). Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging clinical and experimental research, 29(1), 19-27.
Wolfe, R. R. (2017). Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?. Journal of the International Society of Sports Nutrition, 14(1),1-7.
Zhang, S., Xu, H., Yu, X., Wu, Y. I., & Sui, D. (2017). Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes. Experimental and therapeutic medicine, 14(1), 383-390.
Zhu, Y., Guo, X., Zhang, Q., & Yang, Y. (2022). Prognostic value of sarcopenia in patients with rectal cancer: A meta-analysis. Plos one, 17(6),1-11,2022.
